Has 1st person mode.
Customisable HUD.
Each character will have different sets of clothes to coincide with weather conditions.
Clothing customisations go as far as allowing layering and minor adjustments, like the option to roll up your sleeves.
You can physically see all your weapons on Arthur's character model–you can hold only hold two sidearms and two long weapons (along with a knife, lasso, and throwables).
Like the first game you have a range of choices, and your decision affects your honor meter.
It's possible to shoot weapons out of enemy hands
Dead Eye now has 5 levels, Level 1 allows for slowdown, Level 2 allows you to paint targets and unleash a barrage of shots, and Level 3 allows you to manually pick your shooting points, etc.
Gun customisation, such as engravings.
Beard grows over time, but you can shave.
You get hungry over time, but you can get fat if you eat too much, effecting stamina.
Stats like stamina can be raised by doing physical activities (such as in GTA V or Bethesda RPG's).
When hunting, you can sell the carcass or take it to the butchers for meat. If you leave it too long, it'll rot.
Your camp will not wait for you. Members of your gang who reside at camp will come and go, and finding out where exactly they've gone from others will be the basis of a number of quests and side quests.

Les affrontements ont l'air aussi rigide qu'avant donc les allergiques vont pas être ravis... J'attends aussi de voir ce qui sera de l'exploration hors quêtes principales.